Markus Sutter, PhD
Senior Research Associate
Kerfeld Lab West

PhD, ETH Zurich
MS Biochemistry and Biophysics, ETH Zurich

Lawrence Berkeley National Laboratory
Building 64, Room 125
1 Cyclotron Road, Berkeley, California 94720
Phone +1-510-486-6846

[email protected]

Publications (Google Scholar link)

• Ferlez BH, Kirst H, Greber BJ, Nogales E, Sutter M, Kerfeld CA (2023). Heterologous Assembly of Pleomorphic Bacterial Microcompartment Shell Architectures Spanning the Nano- to Microscale Adv Mater 35(23): e2212065. (link)
• Doron L, Sutter M, Kerfeld CA (2023). Characterization of a novel aromatic substrate-processing microcompartment in Actinobacteria mBio: e0121623. (link)
• María Agustina Domínguez-Martín, Paul V. Sauer, Henning Kirst, Markus Sutter, David Bína, Basil J. Greber, Eva Nogales, Tomáš Polívka & Cheryl A. Kerfeld (2022). Structures of a phycobilisome in light-harvesting and photoprotected states Nature 609: 835–845. (link) ​
• USF Genomics Class 2020,  USF Genomics Class 2021, Sutter M, Kerfeld CA, Scott KM (2022). Atypical Carboxysome Loci: JEEPs or Junk? Frontiers in Microbiology 13. (link)
• Sutter M, Kerfeld CA (2022). ​BMC Caller: a webtool to identify and analyze bacterial microcompartment types in sequence data Biology Direct 17 (9). (link) 
• Sutter M, Melnicki MR, Schulz F, Woyke T, Kerfeld CA (2021). A catalog of the diversity and ubiquity of bacterial microcompartments Nature Communications 12(1). (link)
• Asija K, Sutter M, Kerfeld CA (2021). A Survey of Bacterial Microcompartment Distribution in the Human Microbiome Frontiers in Microbiology 12. (link)
• Melnicki MR, Sutter M, Kerfeld CA (2021). Evolutionary relationships among shell proteins of carboxysomes and metabolosomes Current Opinion in Microbiology 63: 1-9. (link)
• Dominguez-Martin MA, Hammel M, Gupta S, Lechno-Yossef S, Sutter M, Rosenberg DJ, Chen Y, Petzold CJ, Ralston CY, Polivka T, Kerfeld CA (2020). Structural analysis of a new carotenoid-binding protein: the C-terminal domain homolog of the OCP Scientific Reports 10(1). (link)
• Kerfeld CA, Sutter M (2020). Engineered bacterial microcompartments: apps for programming metabolism Current Opinion in Biotechnology 65: 225-232. (link)
• Scott KM, Harmer TL, Gemmell BJ, Kramer AM, Sutter M, Kerfeld CA, Barber KS, Bari S, Boling JW, Campbell CP, Gallard-Gongora JF, Jackson JK, Lobos A, Mounger JM, Radulovic PW, Sanson JM, Schmid S, Takieddine C, Warlick KF, Whittaker R (2020). Ubiquity and functional uniformity in CO2 concentrating mechanisms in multiple phyla of Bacteria is suggested by a diversity and prevalence of genes encoding candidate dissolved inorganic carbon transporters Fems Microbiology Letters 367(13). (link)
• Sutter M, Laughlin TG, Sloan NB, Serwas D, Davies KM, Kerfeld CA (2019). Structure of a Synthetic beta-Carboxysome Shell Plant Physiology 181(3): 1050-1058.
• Ferlez B, Sutter M, Kerfeld CA (2019) A designed bacterial microcompartment shell with tunable composition and precision cargo loading Metabolic Engineering Jul;54;286-291 (link)
• Gupta S, Sutter M, Remesh SG, Dominguez-Martin MA, Bao H, Feng XA, Chan LG, Petzold CJ, Kerfeld CA, Ralston CY (2019) X-ray radiolytic labeling reveals the molecular basis of orange carotenoid protein photoprotection and its interactions with fluorescence recovery protein Journal of Biological Chemistry May 31; 294(22):8848-8860 (link)
• Sutter M, McGuire S, Ferlez B, Kerfeld CA (2019) Structural Characterization of a Synthetic Tandem-Domain Bacterial Microcompartment Shell Protein Capable of Forming Icosahedral Shell Assemblies ACS Synth Biol Apr 19;8(4):668-674. (link)
• Dominguez-Martin MA, Polívka T, Sutter M, Ferlez B, Lechno-Yossef S, Montgomery BL, Kerfeld CA (2019)  Structural and spectroscopic characterization of HCP2 Biochimica et Biophysica Acta (BBA) - Bioenergetics May 1;1860(5):414-424 (link)
• Greber BJ*, Sutter M*, Kerfeld CA (2019) The Plasticity of Molecular Interactions Governs Bacterial Microcompartment Shell Assembly Structure May 7;27(5):749-763.e4 (link)
• Sommer M, Sutter M, Gupta S, Kirst H, Turmo A, Lechno-Yossef S, Burton RL, Saechao C, Sloan NB, Cheng X, Chan LG, Petzold CJ, Fuentes-Cabrera M, Ralston CY, Kerfeld CA (2019) Heterohexamers Formed by CcmK3 and CcmK4 Increase the Complexity of Beta Carboxysome Shells Plant Physiology Jan;179(1):156-167 (link)
• Ferlez B, Sutter M, Kerfeld CA (2019) Glycyl Radical Enzyme-Associated Microcompartments: Redox-Replete Bacterial Organelles mBio Jan 8;10(1) pii:e02327-18 (link)
• Pande K, Donatelli JJ, Malmerberg E, Foucar L, Poon BK, Sutter M, Botha S, Basu S, Bruce Doak R, Dörner K, Epp SW, Englert L, Fromme R, Hartmann E, Hartmann R, Hauser G, Hattne J, Hosseinizadeh A, Kassemeyer S, Lomb L, Montero SFC, Menzel A, Rolles D, Rudenko A, Seibert MM, Sierra RG, Schwander P, Ourmazd A, Fromme P, Sauter NK, Bogan M, Bozek J, Bostedt C, Schlichting I, Kerfeld CA, Zwart PH (2018) Free-electron laser data for multiple-particle fluctuation scattering analysis Scientific Data Oct 2;5:180201 (link)
• Hagen A, Sutter M, Sloan N, Kerfeld CA (2018) Programmed loading and rapid purification of engineered bacterial microcompartment shells Nature Communications Jul 23;9(1):2881 (link)
• Cheryl A. Kerfeld, Clement Aussignargues, Jan Zarzycki, Fei Cai & Markus Sutter (2018) Bacterial microcompartments Nature Reviews Microbiology volume 16, pages 277–290 (link) 
• Han Bao, Matthew R. Melnicki, Emily G. Pawlowski, Markus Sutter, Marco Agostoni, Sigal Lechno-Yossef, Fei Cai, Beronda L. Montgomery & Cheryl A. Kerfeld (2017) ​Additional families of orange carotenoid proteins in the photoprotective system of cyanobacteria Nature Plants, 3, 17089 (link)
• ​Markus Sutter, Basil Greber, Clement Aussignargues, Cheryl A. Kerfeld (2017). Assembly principles and structure of a 6.5-MDa bacterial microcompartment shell Science, Vol. 356, Issue 6344, pp. 1293-1297 (link)
• Han Bao, Matthew R. Melnicki, Emily G. Pawlowski, Markus Sutter, Marco Agostoni, Sigal Lechno-Yossef, Fei Cai, Beronda L. Montgomery & Cheryl A. Kerfeld (2017). ​Additional families of orange carotenoid proteins in the photoprotective system of cyanobacteria Nature Plants, 3, 17089 (link)​
• Cheryl A. Kerfeld, Matthew R. Melnicki, Markus Sutter, Maria Agustina Dominguez-Martin (2017) Structure, function and evolution of the cyanobacterial orange carotenoid protein and its homologs Tansley Review / New Phytologist (link)
• Zarzycki J., M. Sutter, N.S. Cortina, T.J. Erb, C.A. Kerfeld (2017). In Vitro Characterization and Concerted Function of Three Core Enzymes of a Glycyl Radical Enzyme - Associated Bacterial Microcompartment Scientific Reports, 16;7:42757 (link)
• Melnicki, M.R., Leverenz, R.L., Sutter, M., López-Igual, R., Wilson, A., Pawlowski, E.G., Perreau, F., Kirilovsky, D., and Kerfeld, C.A. (2016). Structure, Diversity, and Evolution of a New Family of Soluble Carotenoid Binding Proteins in Cyanobacteria. Molecular Plant, advance online publication. (link)
• López-Igual, R., Wilson, A., Leverenz, R.L., Melnicki, M.R., Bourcier de Carbon, C., Sutter, M., Turmo, A., Perreau, F., Kerfeld, C.A, and Kirilovsky, D. (2016). Different functions of the paralogs to the N-terminal domain of the Orange Carotenoid Protein in the cyanobacterium Anabaena sp. PCC 7120. Plant Physiology 171 (3): 1852-1866. (link)
• Erbilgin, O.*, M. Sutter* and C. A. Kerfeld (2016). The Structural Basis of Coenzyme A Recycling in a Bacterial Organelle PLoS Biology 14(3): e1002399. (link)
• Lopez-Igual, R., A. Wilson, R. L. Leverenz, M. R. Melnicki, C. Bourcier de Carbon, M. Sutter, A. Turmo, F. Perreau, C. A. Kerfeld and D. Kirilovsky (2016). "Different functions of the paralogs to the N-terminal domain of the Orange Carotenoid Protein in the cyanobacterium Anabaena sp. PCC 7120." Plant Physiol. (link)
• Aussignargues, C., M. E. Pandelia, M. Sutter, J. S. Plegaria, J. Zarzycki, A. Turmo, J. Huang, D. C. Ducat, E. L. Hegg, B. R. Gibney and C. A. Kerfeld (2016). "Structure and Function of a Bacterial Microcompartment Shell Protein Engineered to Bind a [4Fe-4S] Cluster." J Am Chem Soc 138(16): 5262-5270. (link)
• Sutter, M., M. Faulkner, C. Aussignargues, B. C. Paasch, S. Barrett, C. A. Kerfeld and L. N. Liu (2016). "Visualization of Bacterial Microcompartment Facet Assembly Using High-Speed Atomic Force Microscopy." Nano Letters 16(3): 1590-1595. (link)
• Sutter, M., E. W. Roberts, R. C. Gonzalez, C. Bates, S. Dawoud, K. Landry, G. C. Cannon, S. Heinhorst and C. A. Kerfeld (2015). "Structural Characterization of a Newly Identified Component of alpha-Carboxysomes: The AAA+ Domain Protein CsoCbbQ." Scientific Reports 5: 16243. (link)
• Leverenz, R.L.*, Sutter, M.*, Wilson A., Gupta, S., Thurotte, A., Bourcier de Carbon, C., Petzold, C.J., Ralston, C., Perreau, F., Kirilovsky, D., Kerfeld, C.A. A 12 Å carotenoid translocation in a photoswitch associated with cyanobacterial photoprotection. Science 348 (6242): 1463-1466, 2015. (link)
• Cai, F.,  Sutter, M., Bernstein, S.L., Kinney, J.N. and Kerfeld, C.A. Engineering Bacterial Microcompartment Shells: Chimeric Shell Proteins and Chimeric Carboxysome Shells.  ACS Synthetic Biology 4:444-453, 2015.  (link)
• Cameron, J.C., Sutter, M. and Kerfeld, C.A. The Carboxysome: Function, Structure & Cellular Dynamics.  In The Cell Biology of Cyanobacteria.  Elsevier, eds. Enrique Flores and Antonia Herrero, 2014.
• Sutter, M., S. C. Wilson, S. Deutsch and C. A. Kerfeld (2013). "Two new high-resolution crystal structures of carboxysome pentamer proteins reveal high structural conservation of CcmL orthologs among distantly related cyanobacterial species." Photosynth Res 118(1-2): 9-16 (link)
• Cai, F., M. Sutter, J. C. Cameron, D. N. Stanley, J. N. Kinney and C. A. Kerfeld (2013). "The structure of CcmP, a tandem bacterial microcompartment domain protein from the beta-carboxysome, forms a subcompartment within a microcompartment." J Biol Chem 288(22): 16055-16063 (link)
• Sutter, M., A. Wilson, R. L. Leverenz, R. Lopez-Igual, A. Thurotte, A. E. Salmeen, D. Kirilovsky and C. A. Kerfeld (2013). Crystal structure of the FRP and identification of the active site for modulation of OCP-mediated photoprotection in cyanobacteria Proc Natl Acad Sci USA 110(24): 10022-10027  (link)
• Ozcelik, D., J. Barandun, N. Schmitz, M. Sutter, E. Guth, F. F. Damberger, F. H. Allain, N. Ban and E. Weber-Ban (2012). "Structures of Pup ligase PafA and depupylase Dop from the prokaryotic ubiquitin-like modification pathway." Nature Communications 3: 1014, (link)
• Ranjan, N., F. F. Damberger, M. Sutter, F. H. Allain and E. Weber-Ban (2011). "Solution structure and activation mechanism of ubiquitin-like small archaeal modifier proteins." J Mol Biol 405(4): 1040-1055, (link)
• Imkamp, F., F. Striebel, M. Sutter, D. Ozcelik, N. Zimmermann, P. Sander and E. Weber-Ban (2010). "Dop functions as a depupylase in the prokaryotic ubiquitin-like modification pathway." EMBO Reports 11(10): 791-797, (link)
• Sutter, M., F. F. Damberger, F. Imkamp, F. H. Allain and E. Weber-Ban (2010). "Prokaryotic ubiquitin-like protein (Pup) is coupled to substrates via the side chain of its C-terminal glutamate." J Am Chem Soc 132(16): 5610-5612, (link)
• Sutter, M., F. Striebel, F. F. Damberger, F. H. Allain and E. Weber-Ban (2009). "A distinct structural region of the prokaryotic ubiquitin-like protein (Pup) is recognized by the N-terminal domain of the proteasomal ATPase Mpa." FEBS Letters 583(19): 3151-3157, (link)
• Striebel, F., F. Imkamp, M. Sutter*, M. Steiner, A. Mamedov and E. Weber-Ban (2009). "Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes." Nat Struct Mol Biol 16(6): 647-651, (link)
• Sutter, M., D. Boehringer, S. Gutmann, S. Gunther, D. Prangishvili, M. J. Loessner, K. O. Stetter, E. Weber-Ban and N. Ban (2008). "Structural basis of enzyme encapsulation into a bacterial nanocompartment." Nat Struct Mol Biol 15(9): 939-947, (link)
• Gutmann, S., P. W. Haebel, L. Metzinger, M. Sutter, B. Felden and N. Ban (2003). "Crystal structure of the transfer-RNA domain of transfer-messenger RNA in complex with SmpB." Nature 424(6949): 699-703, (link)

*contributed equally