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Jeff Plegaria, PhD
Postdoctoral Researcher Plant Research Laboratory, Michigan State University-DOE Kerfeld East PhD, Chemistry, University of Michigan, Ann Arbor, MI, 2015 BSc, Chemistry, La Salle University, Philadelphia, PA, 2007 Michigan State University 612 Wilson Road, Room 222 East Lansing, MI 48824 Phone 517-432-4349 plegaria@msu.edu |
My current research interest involves engineering redox-active centers on and inside BMC protein shells to study electron transfer and redox-coupled reactions.
Publications
Publications
- Plegaria, J. S. and V. L. Pecoraro (2016). De Novo Design of Metalloproteins and Metalloenzymes in a Three-Helix Bundle. Computational Design of Ligand Binding Proteins. L. B. Stoddard. New York, NY, Springer New York: 187-196.
- Aussignargues C, Pandelia ME, Sutter M, Plegaria JS, Zarzycki J, Turmo A, Huang J, Ducat DC, Hegg EL, Gibney BR, Kerfeld CA (2015) Structure and Function of a Bacterial Microcompartment Shell Protein Engineered to Bind a [4Fe-4S] Cluster. J. Am. Chem. Soc.
- Plegaria JS, Duca M, Tard C, Friedlander TJ, Deb A, Penner-Hahn JE, Pecoraro VL (2015) De novo design and characterization of copper metallopeptides inspired by native cupredoxins. Inorg. Chem., 54(19), 9470-9482.
- Plegaria JS, Herrero C, Quaranta A, Pecoraro VL.(2015) Electron transfer activity of a de novo designed copper center in a three-helix bundle fold. Biochim Biophys Acta.
- Plegaria, J. S., Dzul, S., Zuiderweg, E. R. P., Stemmler, T. L., and Pecoraro, V.L. (2015) Apoprotein Structure and Metal Binding Characterization of a De Novo Designed Peptide, α3DIV, that Sequesters Toxic Heavy Metals. Biochemistry 54, 2858−2873.
- Plegaria, J. S., and Pecoraro, V.L. (2015) Sculpting Metal Binding Environments in De Novo Designed Three-Helix Bundles, Isr. J. Chem., 55, 85-95.
- Yu, F., Cangelosi, V., Zastrow, M., Tegoni, M., Plegaria, J. S., Tebo, A., Mocny, C., Ruckthong, L., Qayyum, H., and Pecoraro, V.L. (2014) Protein Design: Toward Functional Metalloenzymes, Chem. Rev., 114, 3495-3578.
- Bresler, S. C., Wood, A. C., Haglund, E. A., Courtright, J., Belcastro, L. T., Plegaria, J. S., Cole, K., Toporovskaya, Y., Zhao, H., Carpenter, E. L., Christensen, J. G., Maris, J. M., Lemmon, M. A., and Mossé, Y. P. (2011) Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma, Science Translational Medicine, 3, 108ra114.